Doctor Doom

With: Morningstar

Doctor Doom: Successful Nullifies deal a burst of energy damage equal to 20% of Doom’s Attack.

With: Thing, Human Torch, Invisible Woman, Mister Fantastic

All Champions: +6% Attack Rating.

With: Baron Zemo

Synergy Champions: +300 Critical Rating when fighting Skill or Cosmic Opponents, +300 Block Proficiency when fighting Science or Tech Opponents, and +30% Regeneration Rate when fighting Mystic or Mutant Opponents. Gain all bonuses when fighting Superior Opponents.

With: Diablo

All Champions: +115 Critical Damage Rating.

With: Doombot (Cosmic), Doombot (Tech), Doombot (Mutant), Doombot (Skill), Doombot (Science), Doombot (Mystic)

All Doombots: Start each fight with an indefinite Heavy Proficiency Passive, increasing Attack Rating by +15% during Heavy Attacks.

With: Iron Man (Infamous)

Hero Champions: +8% Attack Rating. Robot Champions: +20% Ability Accuracy.

With: Magneto

Magneto: While fighting #Hero Champions, Special Attacks gain +15% Attack rating and gain a Cruelty Buff lasting 14 seconds and increasing Critical Damage Rating by 800.

With: Mister Fantastic

Mister Fantastic: Gain 5% of his Max Power each time a Buff is Nullified or its Duration expires off the Opponent. Doctor Doom: Heavy Attacks apply up to 1 Armor Break Debuff for 10 second(s), reducing Armor Rating by 15%.

With: Mole Man

Mole Man: While Frenzied, Mole Man’s attacks lower Defensive Ability Accuracy by 50% fighting against the #Fantastic Four. Doctor Doom: 20% chance to Purify a Debuff.

With: Platinumpool

Platinumpool: Increase the chance to draw the Sumopool

With: Punisher 2099

All Champions: +5% Perfect Block Chance.

With: Silver Surfer

All Champions: +155 Critical Rating.

With: Spider-Man (Miles Morales)

All Champions: +6% Attack Rating.

With: Spider-Man 2099

All Champions: +155 Critical Rating.

With: Squirrel Girl

Squirrel Girl: When Tippy-Toe would Purify all non-damaging Debuffs on Squirrel Girl, also Purify 1 damaging Debuff(s). This can only be used once per fight. Doctor Doom: Doctor Doom’s Aura of Haazareth

With: Super-Skrull

Super-Skrull: Start the fight with a Vigilance Buff, which prevents their attacks from Missing, and lasts 15 seconds.

With: The Leader

All Champions: +5% Perfect Block Chance.

With: The Maker

The Maker: At the start of each fight and when activating a Special Attack 3, inflict a non-stacking Ensnare Passive for 15 seconds, refreshed on knockdown. Doctor Doom: Heavy Attacks can no longer Critically Hit, but instead they gain +40% Attack Rating.

With: The Overseer

All Champions: +155 Critical Rating.

With: Titania

Titania: Debuffs gain +50% Ability Accuracy for each other Synergy Champion present, increased to +100% for each defeated Synergy Champion. Does not affect Debuffs from Titania’s Signature Ability.