Doctor Octopus

With: Baron Zemo

Synergy Champions: +300 Critical Rating when fighting Skill or Cosmic Opponents, +300 Block Proficiency when fighting Science or Tech Opponents, and +30% Regeneration Rate when fighting Mystic or Mutant Opponents. Gain all bonuses when fighting Superior Opponents.

With: Black Cat

All Champions: +155 Critical Rating.

With: Diablo

Diablo: Special Attacks have a 70% chance to inflict a Stun Debuff, lasting 1.5 second(s) per level of Special Attack used. Doctor Octopus: +35% Heal Block Debuff duration.

With: Doctor Doom

Doctor Doom: Shock and Incinerate Debuffs have +20% increased Potency.

With: Elsa Bloodstone

All Champions: +155 Critical Rating.

With: Imperiosa

Imperiosa: Gain personal Special Lock Immunity after Dodging a Basic Attack. Doctor Octopus: Increase personal burst damage potency by 15%.

With: Ironheart

All Champions: +155 Critical Rating.

With: Jubilee

Synergy Champions: +10% Max Health.

With: Kindred

Synergy Champions: +15% Attack Rating against #Spider-Verse Heroes.

With: Kraven

Synergy Champions: When fighting #Heroes Combat Power Rate is increased by 25%.

With: Lizard

Synergy Champions: When fighting against #Spider-Verse Heroes, on Special Attack activation, gain a Pursuit Passive for 13 seconds.

With: M.O.D.O.K.

All Champions: +15% Attack Rating once a combo of 15 or more hits is reached.

With: Mister Fantastic

Tech and Science Champions: Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times.

With: Mister Negative

All Champions: +155 Critical Rating.

With: Sandman

All Champions: +5% Perfect Block Chance.

With: Scorpion

All Champions: +5% Perfect Block Chance.

With: Shocker

Synergy Champions: +250 Critical Resistance, doubled when fighting #Spider-Verse Heroes.

With: Spider-Man (Classic)

Spider-Man (Classic): Heavy Attack inflicts a non-stacking Injury Debuff for 13 seconds. Hitting an Injured Opponent bypasses 100% of Physical Resistance. Doctor Octopus: 15% chance to Evade attacks for each active Breakthrough. Does not trigger while Blocking.

With: Spider-Man 2099

All Champions: +155 Critical Rating.

With: Spider-Slayer (J. Jonah Jameson)

All Champions: +155 Critical Rating.

With: Venom

All Champions: +115 Critical Damage Rating.

With: Vulture

All Champions: +5% Perfect Block Chance.