Doctor Strange

With: Spider-Man (Classic)

All Champions: +130 Armor Rating.

With: Black Bolt

All Champions: +5% Perfect Block Chance.

With: Scarlet Witch (Classic)

All Champions: +5% Perfect Block Chance.

With: Bishop

Bishop: Start the fight with +2 Prowess and +1 Bar of Power. Doctor Strange: +15% Energy Resistance.

With: Black Widow (Claire Voyant)

Black Widow (Claire Voyant): The final hit of Special 2 has a 50% chance to inflict a Stun Debuff for 2 seconds. Doctor Strange: The final 3 hits of Special Attack 2 inflict either Poison

With: Blade (Stellar-Forged)

All Champions: +5% Perfect Block Chance.

With: Captain America (Infinity War)

Mystic Champions: Deal 30% of their Attack as Direct Damage to their Opponent when Nullifying one of their Buffs.

With: Corvus Glaive

All Champions: +7% Attack Rating.

With: Count Nefaria

Synergy Champions: Block Proficiency increased by +400.

With: Cull Obsidian

All Champions: +155 Critical Rating.

With: Doctor Doom

Doctor Doom: Activating the Aura of Haazareth

With: Doctor Voodoo

All Champions: +115 Critical Damage Rating.

With: Dormammu

All Champions: +6% Attack Rating.

With: Ebony Maw

All Champions: +155 Critical Rating.

With: Ghost Rider

Midnight Sons: Once per fight, activating a Special Attack grants a 20% Rejuvenate Passive for 15 seconds.

With: Howard the Duck

Howard the Duck: The Opponent suffers -65% Evade Ability Accuracy. Other Synergy Champions: Up to +15% Attack Rating based on missing Health.

With: Hyperion

All Champions: +155 Critical Rating.

With: Ikaris

Ikaris: When a personal Incinerate expires naturally or is purified, there is a 30% chance to re-inflict it. Doctor Strange: The first time Doctor Strange is struck in each fight, he gains a 5% Safeguard Buff for 10 seconds.

With: Iron Fist

All Champions: +130 Armor Rating.

With: Iron Fist (Immortal)

All Champions: +130 Armor Rating.

With: Iron Man (Infamous)

Iron Man (Infamous): Cowardice effects gain 50% increaased potency. Doctor Strange: During Special Attack 1, gain +40% Attack Rating.

With: Jabari Panther

Synergy Champions: +10% Ability Power Rate.

With: Juggernaut

All Champions: +5% Attack Rating.

With: Kushala

Synergy Champions: Special Attack 3 grants a non-stacking 10% Amplify Passive for 15 seconds.

With: Mephisto

Mephisto: +70% increased Incinerate potency. Doctor Strange: +10% increased Regeneration potency.

With: Mister Fantastic

Mutant and Mystic Champions: Regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight.

With: Mordo

All Champions: +6% Attack Rating.

With: Negasonic Teenage Warhead

Negasonic Teenage Warhead: While below 5% Health, the chance to Evade Medium and Light Attacks with Precognition becomes 100% until an Evade activates. Synergy Champions: +10% Health.

With: Pixie

Pixie: Oshtur’s Refusal Doctor Strange: The Wither Passives inflicted by Oshtur’s Refuge have their potency increased by 50%.

With: Proxima Midnight

All Champions: +7% Attack Rating.

With: Sauron

Synergy Champions: Whenever the Opponent gains a Regeneration effect, gain a non-stacking Regeneration Passive healing 2% of Max Health over 2 seconds. This goes on Cooldown for 5 seconds. When it ends, it goes on cooldown for 5 seconds. Every 4th of these Regenerations that would be gained instaed inflicts the Opponent with a Heal Block Passive for 12 seconds.

With: Scarlet Witch

All Champions: +6% Health.

With: Silver Surfer

Silver Surfer: Reduce the cooldown of Silver Surfer’s Power Cosmic Buff by 3 seconds. Doctor Strange: Increase the Potency of Doctor Strange’s Vishanti Blessings by 25%.

With: Sorcerer Supreme

Synergy Champions: Activating a Blessing grants a +15% Prowess Passive until the end of the next Special Attack. Max stacks: 3.

With: Spider-Man (Pavitr Prabhakar)

Synergy Champions: At the start of each fight, rapidly gain 50% of a Bar of Power.

With: Spider-Slayer (J. Jonah Jameson)

Synergy Champions: Intercepting the Opponent grants a non-stacking +15% Confidence Passive for 10 seconds.

With: Symbiote Supreme

Symbiote Supreme: Start each fight with 1 bar of Power. Doctor Strange: When a Buff on the Opponent is Nullified, deal 50% of Base Attack as a burst of Direct Damage.

With: The Hood

All Champions: +155 Critical Rating.

With: Thor

All Champions: +130 Armor Rating.

With: Vision (Aarkus)

All Champions: +5% Perfect Block Chance.

With: Void

All Champions: +155 Critical Rating.

With: Wong

Wong: Maximum Eldritch Energy Doctor Strange: Personal Fate Seals gain 50% increased duration.