Mister Fantastic

With: Doctor Doom

Mister Fantastic: +5% of his Max Power each time a Buff is Nullified or its Duration expires off the Opponent. Doctor Doom: Heavy Attacks apply up to 1 Armor Break Debuff for 10 second(s), reducing Armor Rating by 15%.

With: Groot, Angela, Masacre, Night Thrasher

With: Sentry, She-Hulk, Vulture, Doctor Octopus

With: Psylocke, Storm, Doctor Strange, Loki

With: Air-Walker

All champions: +155 Critical Rating.

With: Annihilus

All champions: +155 Critical Rating.

With: Attuma

All champions: +155 Critical Rating.

With: Diablo

All Champions: +6% Attack Rating.

With: Doctor Doom

Doctor Doom: Shock and Incinerate Debuffs have +20% increased Potency.

With: Doctor Doom

All Champions: +6% Attack Rating.

With: Dragon Man

Dragon Man: Ineptitude reduces the Opponents Armor Rating, Attack Rating, Critical Rating, and Critical Damage Rating by 10%. Mister Fantastic: Each Careful Study Passive on the Opponent increases Mister Fantastic’s matching Special Attacks damage by 50%.

With: Galan

Galan: All Incinerate Debuff durations are increased by 50%. Mister Fantastic: Whenever a Personal Debuff expires on the Opponent, gain 20% of a bar of power.

With: Gamora

Gamora: +20% Fury & Cruelty Buff Potency. Synergy Champions: +5% Attack Rating.

With: Hulkbuster

Hulkbuster: Each Shock Debuff reduces the opponent’s Offensive Ability Accuracy during Special Attacks by 15%. Mister Fantastic: +1000 Physical Resistance.

With: Human Torch

Other Synergy Champions: The last hit of Special Attack 1 Incinerated the Opponent for 6 second(s). This also inflicts Heal Block if all other Champions in this Synergy are present.

With: Invisible Woman

Other Synergy Champions: Block Proficiency increased by 5%. Perfect Block chance increased by 10%. If all other Champions in this Synergy are present, Well-Timed Blocks inflict up to one 10% Weakness Debuff on the Opponent for 6 second(s).

With: Invisible Woman

Invisible Woman: When the Opponent activates a Special Attack, if the Force Field is active, it gains 10% strength for each Bar of Power spent.

With: Iron Man (Infamous)

Iron Man (Infamous): +4900 Critical Rating while the Opponent has 2 or more Bars of Power. Mister Fantastic: Imprison the Opponent’s Soul at the start of the fight, reducing their chance to activate Buffs by 100% for 15 seconds.

With: Mole Man

All champions: +155 Critical Rating.

With: Psycho-Man

All champions: +155 Critical Rating.

With: Shuri

Synergy Champions: Start each fight with an indefinite Failsafe Charge. When struck by a Special Attack 1 or 2, consume the Failsafe to gain an Indestructible Passive for the duration of the Special.

With: Silver Surfer

All champions: +130 Armor Rating.

With: Super-Skrull

Other Synergy Champions: Block Proficiency increased by 5%. Perfect Block chance increased by 10%. If all other Champions in this Synergy are present, Well-Timed Blocks inflict up to one 10% Weakness Debuff on the Opponent for 6 second(s).

With: Super-Skrull

Other Synergy Champions: The last hit of Special Attack 1 Incinerated the Opponent for 6 second(s). This also inflicts Heal Block if all other Champions in this Synergy are present.

With: Super-Skrull

Other Synergy Champions: The last hit of Special Attack 2 grants a Fury Buff for 6 seconds(s), increasing Attack by 15% of Base Attack. This effect is doubled if all other Champions in this Synergy are present.

With: The Maker

The Maker: Increase Attack Rating by 0%. The potency of this synergy is increased by a flat +30% for each other Reed Richards on your team. Synergy Champions: The potency increase in all Council of Reeds synergies account for all versions of Reed Richards.

With: Thing

Other Synergy Champions: The last hit of Special Attack 2 grants a Fury Buff for 6 seconds(s), increasing Attack by 15% of Base Attack. This effect is doubled if all other Champions in this Synergy are present.