Red Skull

With: Captain America (WWII)

Red Skull: Well-Timed Blocks have a +10% chance to Perfect Block for each Buff on Red Skull. Captain America (WWII): Well-Timed Blocks generate a Fury Buff increasing Base Attack by 20% for 5 seconds.

With: Kingpin, Loki, Iron Patriot, M.O.D.O.K.

All Villains: +20% Armor.

With: Punisher 2099

Red Skull: Intercepts Heal Block the opponent for 7.5 seconds. Punisher 2099: Duration of Heal Block, Armor Break, and Power Lock Debuffs are increased by 50%.

With: Abomination (Immortal)

Abomination (Immortal): The Basic Attacks required to trigger a Self-Poison are reduced by 2. Red Skull: The final hit of Special Attack 1 refreshes all Personal Heal Block Debuffs on the Opponent.

With: Arnim Zola

#Hydra Champions: Start each fight with an indefinite +10% Lying In Hate Passive.

With: Crossbones

Mercenary & Villain Champions: +5% Health & +400 Critical Damage Rating. Crossbones: [Contempt]

With: Diablo

Diablo: Personal Poison Debuffs become Passive and gain +10% Potency. Red Skull: +10% Shock Debuff Potency.

With: Doctor Doom

Doctor Doom: +15% Perfect Block chance.

With: Guillotine

All Champions: +6% Attack Rating.

With: Maestro (Cosmic)

Synergy Champions: +100 Armor Rating, +100 Critical Rating, +100 Critical Damage Rating, and +3% Perfect Block Chance, doubled when fighting the final node in a Quest.

With: Odin

All Champions: +155 Critical Rating.

With: Omega Red

Omega Red: Well Timed Blocks have a 100% chance to inflict 1 Death Spore up to a max of 30 Spores total. Red Skull: Each hit of Special Attack 1 Invalidates 1 Prowess from the Opponent.

With: Onslaught

Onslaught: Against Skill Champions, while attacking, Onslaught Passively Regenerates 85% of incoming Physical Damage.

With: Spider-Woman (Jessica Drew)

Spider-Woman (Jessica Drew): Against Mystic Champions, gaining a Buff inflicts a 50% Concussion Passive for 0.5 seconds which cannot affect Nodes. While in a fight, count as #Hydra and a #Villain instead of a #Hero. Red Skull: On a Well-Timed Block, 25% chance to not lose an Armor Up Buff.

With: The Overseer

The Overseer: 50% chance to gain an Indefinite Gamma Power when the Opponent launches a Special while taunted. Red Skull: 8% chance per Armor Up to inflict an Armor Break Debuff on Special 2 attacks, reducing Armor Rating by 562 for 15 second(s).