Spider-Man (Classic)

With: Agent Venom

All Champions: +4% Health & Attack.

With: Ant-Man

All Champions: +5% Perfect Block Chance.

With: Arcade

All Champions: +155 Critical Rating.

With: Black Bolt

All Champions: +130 Armor Rating.

With: Black Cat

Black Cat: While the Heist is not active, gain a 10% chance to Evade for each #Spider-Verse Heroes team member. Spider-Man (Classic): On Evade, inflict a Physical Vulnerability Debuff reducing the Opponent's Physical Resistance by 413 for 30 second(s).

With: Captain America

All Champions: +130 Armor Rating.

With: Carnage

All Champions: +6% Attack Rating.

With: Doctor Octopus

All Champions: +6% Attack Rating.

With: Doctor Strange

All Champions: +130 Armor Rating.

With: Ebony Maw

All Champions: +155 Critical Rating.

With: Electro

All Champions: +5% Attack Rating.

With: Green Goblin

Green Goblin: +15% Pumpkin Bomb damage for each Cunning and Madness charge. Spider-Man Champions: Critical Hits generate 15% more Power.

With: Guardian

All Champions: +5% Perfect Block Chance.

With: Hit-Monkey

Hit-Monkey: When fighting #Mercenary Opponents, gain the effects of the level 1 Assassin Mastery. If the Assassin Mastery is already acquired, it instead activates when the Opponent is below 25% of their Maximum Health. Spider-Man (Classic): 6+ Webbing: Fragility Debuff that increaases the Critical Damage Rating of incoming Hits by 2400 and reduces Block Proficiency by 50%.

With: Iceman

All Champions: +115 Critical Damage Rating.

With: Iron Patriot

All Champions: +155 Critical Rating.

With: Jack O'Lantern

All Champions: +155 Critical Rating.

With: Jessica Jones

All Champions: +6% Health.

With: Kindred

Kindred: +10% Degeneration effect potency.

With: Kraven

Kraven: Once per Fight when receiving damage that would result in a knockout, gain an Immortality Buff preventing death for 8 second(s). Spider-Man (Classic): 8+ Webbing: Root Debuff lasting 2 seconds.

With: Lizard

All Champions: Gain a Lizard Regeneration Passive at the start of each fight, granting +1100 Attack Rating and recovering 2% of Base Health over 20 seconds. Synergy Champions: Increase the amount healed by Lizard Regeneration by +3% flat.

With: Mister Negative

#Spider-Verse Heroes: Start the fight with 2 indefinite Passive Dark Energy

With: Moon Knight

All Champions: +130 Armor Rating.

With: Mysterio

All Champions: +8% Attack Rating.

With: Onslaught

All Champions: +155 Critical Rating.

With: Prowler

Prowler: If the Opponent is not Faltered, Prowler has a 20% chance to Evade Basic Attacks while not Blocking. Spider-Man (Classic): For each stack of Webbing on the Opponent, Special Attack 2 deals 10% of Attack Rating as a burst of Physical Damage.

With: Punisher

All Champions: +115 Critical Damage Rating.

With: Red Goblin

All Champions: +6% Attack Rating.

With: Rhino

All Champions: +155 Critical Rating.

With: Scorpion

All Champions: +155 Critical Rating.

With: Shang-Chi

Shang-Chi: Critical Hits bypass +20% of Armor and Resistances. Spider-Man (Classic): Spider-Man can use Perfect-Timing while performing a Well-timed Block or Dodging an Attack to inflict a Physical Vulnerability Debuff reducing the Opponent's Physical Resistance by 1400 for 30 seconds. Max: 3 stack(s).

With: Shathra

Spider-Man (Classic): If this Champion is a Wasp-Totem, Spider-Man’s personal Taunt Ability Accuracy is increased by 75%. Additionally, at 7+ stacks of Webbing, inflict a 30% potency Wither Debuff.

With: Shathra

Shathra: For each dead Synergy Member on the team, Shathra gains +6% Atk Rating. #Spider-Verse Heroes: For each alive #Spider-Verse Heroes Champion on the team, gain +6% Attack Rating.

With: Shocker

Shocker: At 50+ Vibro-Shock Charges, Defenders are 50% more likely to activate Special Attacks.

With: Silk

Silk: Special Attack 2 inflicts stacks of Webbing. Webbing falls off slowly as the Opponent attacks and moves. For each stack of Webbing, personal bursts of damage gain +5% potency. Max stacks: 10. Spider-Man (Classic): The first time in each fight Spider-Man would be struck by a Special Attack, he gains a 100% chance to Evade the rest of the Special Attack.

With: Silver Sable

Spider-Man (Classic): While at 5+ Webbing, inflict an indefinite Shock Debuff dealing 60% of Attack as Energy Damage per second. Silver Sable: Decrease the cooldown on Sable Mines by 2 seconds.

With: Silver Samurai

All Champions: +155 Critical Rating.

With: Spider-Gwen

All Champions: +5% Combat Power Rate.

With: Spider-Ham

All Champions: +5% Perfect Block Chance.

With: Spider-Man (Miles Morales)

All Champions: +4% Health & Attack Rating.

With: Spider-Man 2099

Spider-Man 2099: Gain 100% chance to Evade the first time he is struck in a fight. Spider-Man (Classic): Gain an Unstoppable Passive for 1 second(s) after an Evade triggers. This effect has a 9 second(s) cooldown.

With: Spider-Slayer (J. Jonah Jameson)

Spider-Slayer (J. Jonah Jameson): Start each fight furious with 1 personal Fury Passive. This effect does not stack with duplicate synergies. All Champions: +155 Critical Rating.

With: Spider-Woman (Jessica Drew)

Synergy Champions: +5% Combat Power Rate, or +10% against #Symbiote and #Sinister Six Champions.

With: Spot

Spot: When untouchable starts, inflict a 40% Taunt Debuff for 7 seconds. Spider-Man (Classic): Gain 100% chance to Evade the first he is struck each fight.

With: Storm (Pyramid X)

Synergy Champions: Evade Ability Accuracy is increased by 30% and after activating Evade, inflict Stun for 2 seconds. Both of these effects enter cooldown for 12 seconds after this Stun is activated.

With: Venom

All Champions: +6% Attack Rating.

With: Vulture

All Champions: +155 Critical Rating.

With: White Tiger

Synergy Champions: +4% Perfect Block Chance for each unique Synergy Champion on the team. If all Synergy Champions are present, also gain +30% Attack Rating.